Solar System

But the fool on the hill sees the Sun going down
And the eyes in his head see the world spinning round

I have been watching Brian Cox's series Solar System in absolute astonishment for the past five weeks. Our solar system is bigger and far more complex than we could have imagined only just a few years ago. 

I write this from memory, so may have some things wrong. Whatever I write cannot possibly do the series justice. 

Most of us grew up with nine planets, more recently reduced to eight, but the latest telescopes and space exploration reveal infinitely more objects within the sun's gravitational field than this. Many are very small, while others are quite large. 

And while we may have thought there was little beyond the dwarf planet Pluto, there seem to be millions of icy objects in the same region, known as the Kuiper belt. The largest known so far, discovered only in recent years in the darkness, has been nicknamed FarFarOut. All these objects, like the planets, orbit the sun in the same plane, but even further out lies an enormous sphere of rocks and particles a light year across. It contains mobile objects that travel across the heavens and approach the earth from all directions. They are the comets. 

It is not just the number of objects that is astonishing. It is the variety. They can be made of rock, gas, water ice, nitrogen ice, or something else. Ice can form mountains and canyons ten times the size of those on Earth. Other objects have internal heat sources that create violent monsoons, dust storms, or volcanoes that shoot out into space. 

How these phenomena have formed can often be deduced from space probe photographs and other data. They are subject to similar physical and geological processes whatever they may be made of. Underlying it all are just a small number of forces, mainly gravity. But the gravity of different objects can interact in numerous ways. Some are heated by gravitational friction, alternately squeezed and released by the gravity of a larger planet. 

There are some very strange objects indeed. Once above a few kilometres in size, objects will be shaped by gravity into a sphere, but one body has been seen to defy this law. This is thought to be because it rotates at eight times the speed of the earth, which flattens it into an elliptical shape through centrifugal force. 

The strange rings of Saturn are also down to gravity. They consist of particles of various sizes, possibly from a decaying moon. They orbit at different rates, and the larger objects are gradually speeding and slowing the others with the eventual outcome that all the particles will fall down to the surface of the planet. They have not been there forever, and will in time disappear. It is only coincidence that we are here at the same infinitesimal moment in time, able to see them. 

Ganymede, the largest moon of Jupiter, has a salt lake of water beneath the rocky surface, more than all the water on Earth. This was deduced from the magnetic aurora of the moon, which does not behave as it otherwise should. It has all the conditions we think necessary to support life. What form aqueous life buried deep inside a moon or planet might take, we cannot begin to guess.

But the strangest planet of all is the Earth. It is the only one with liquid water on the surface, maintained by a combination of gravity, temperature, and atmospheric pressure. If different, the water would boil away into space, or freeze solid.

What I like about Brian Cox is that he explains these processes, and how they have been worked out, in lay terms, without exaggeration or the loud, overenthusiastic excitement that spoils so many documentaries these days. Give him the concentration he deserves, and you are rewarded. What he is telling us speaks for itself. It is outrageous. And he laughs, as if he cannot quite believe it either. 

Then I thought about looking into the night sky and the millions of stars in our Milky Way galaxy, probably most with solar systems of their own as complex as ours. And the billions of stars and planets in all the other galaxies there are. And the time scales involved: thousands of billions of earth years. 

Unimaginable. Beyond belief. Beyond understanding. 

The R100

New Month Old Post: first posted 10th July 2016.

In his autobiography, Slide Rule, the author Nevil Shute (1899-1960), a man of his time with attitudes to match, remembered working as an engineer on the R100 airship during its construction at Howden in Yorkshire in the nineteen-twenties. Much of the workforce consisted of local lads and girls trained to carry out riveting and other tasks high up in the ribs and spines of the airship skeleton. Of them he writes:

The lads were what one would expect, straight from the plough, but the girls were an eye-opener. They were brutish and uncouth, filthy in appearance and in habits ... these girls straight off the farms were the lowest types that I have ever seen in England, and incredibly foul-mouthed ... we had to employ a welfare worker to look after them because promiscuous intercourse was going on merrily in every dark corner ... as the job approached completion ... we were able to get rid of the most jungly types. 

Jungly types? That is my maternal grandma you are talking about, Nevil, and her friends and cousins. They never had the chance to be privately educated and scrape through Oxford with a bad degree. While your evenings and weekends were spent dancing, playing badminton, flying aeroplanes and writing novels, they were toiling away tending crops and animals from their damp and dingy dwellings. Better check your privilege. 

And, how come the lads were “salt-of-the-earth, vital rustic types”, while their sisters were “jungly beyond vulgarity”? How was it different from when you were in the army? 

The language of the men was no novelty to me, of course, and I could out-swear most of them, but their attitude to women was shocking... 

Workers at Howden, high up in the ribs and spines of the R100 skeleton.

Both my parents had memories of the R100. My mother’s mother worked there for a short time, and had a small, airship-shaped piece of duralumin silver metal, around an inch and a half long (4cm) and flat on one side. It was from a batch of airship brooches unfinished when they ran out of metal. She gave me it as a toy and it became an imaginary submarine. 

My dad remembered going to see the R100 in its construction shed at Howden. His dad borrowed the Model T van from work to drive there across the newly opened Boothferry Bridge. He said that the river was swollen by floodwater. Looking up in the shed, the airship was so big my dad could not see it. At 700 feet long (220m) and 130 feet in diameter (40m), it was around the size of two rows of twenty-five terraced houses with front gardens and a road between. He thought he was looking up at the roof.

The R100 in its construction shed at Howden
with one of the control gondolas hanging from the airship
which my dad thought was the roof.

The R100 squeezed out of its shed and left for Cardington in Bedfordshire in December, 1929. It was one of two airships built in competition to explore the possibility of commercial flights to Canada, India, and Australia, then still too far for aeroplanes to carry heavy loads. The other was the R101 built at Cardington. 

No more large airships were built in Britain. The R100, the better of the two, made a successful flight to Canada and back in 1930, crossing the Atlantic in three days. Rather than admit defeat, the R101 team attempted a premature flight to India, but the airship hit the ground and caught fire in France in October, 1930, with the loss of 48 lives. The airship project was abandoned and the R100 broken up for scrap. Large airships were built later in other countries, such as the Hindenburg in Germany, but these also ended in disaster. They were filled with hydrogen. 

The R100 over Montreal, August, 1930.

Mutations

This story on the BBC caught my attention because of its similarities to my own situation. 

My heart goes out to this young mother who, aged 33, has been diagnosed with cancer. After two weeks of “migraine”, she was persuaded to see a doctor, who immediately sent her to hospital. Two hours later, she was talking to an oncologist. An MRI scan had revealed 7 brain tumours, and a later CT scan found 3 in her lungs, which was the primary site. 

As I understand it, all tumours are gene mutations. She has a mutation of the ALK gene that produces a rogue protein that causes affected cells to grow uncontrollably. It can be controlled by a new wonder drug called Brigatinib which blocks the action of the protein. I have a similar but different mutation. 

An enormous amount of research is going into the genes involved in different kinds of cancer, and the precise mutations involved. In some cases, drugs can disrupt the growth of affected cells. More and more of these treatments will emerge in the coming years, but development is expensive. Drug companies charge thousands a month to recover their costs. Brigatinib is £5,000 a month; the Tepotinib I take is £7,000 (less confidential NHS discounts). It amounts to many tens of thousands per patient per year. The financial implications for the NHS and health insurers are astronomical.

Is it worth, say, £100,000 to prolong someone’s life for two years? For 10,000 new NHS lung cancer patients each year that amounts to £1 billion per year. What about other forms of cancer? What about other health conditions? What about other issues in the broader arena of health and social care? At some point, the answer will be no.  

Computers, Education and the Conservatives

Conservative governments are non-interventionist. They do not like the state to run anything. They spent the 1980s and 1990s selling off the country’s assets and giving away the proceeds. It continues today in their unwillingness to pay for public services or regulate things properly. Some of them would privatise health and education if they could get away with it. That is why, if my health holds out, I will not be voting Conservative at the next election. I will see the bastards* go to hell before I do. 

And yet, in the 1980s, they did intervene. A 1978 television documentary, ‘Now the Chips are Down’, made clear how woefully unprepared Britain was for the silvery white heat of the computer revolution. It scared the Thatcher government so much that they funded a number of costly initiatives. Two in particular stood out for me.  

A few of the many programmes in the BBC Computer Literacy Archive
https://clp.bbcrewind.co.uk/programmes

In one, the BBC was recruited to raise awareness of the skills needed. It led to the ‘Computer Literacy Project’, which ran from 1982 to 1989. It was linked to the specially commissioned ‘BBC Micro’, which was taken up by many homes and most schools, with over a million sold.

In the other, the ‘Microelectronics Education Programme’, massive amounts of money were spent putting computers in schools, setting up and funding resource centres, and training teachers. Politicians boasted that Britain led the world in “equipping the children of today with the skills of tomorrow.”    

Did it actually achieve anything, or was it bluster and spin?

At least it got my new career off the ground. After escaping from accountancy into a dream job as a university researcher, I knew as much about these new concepts and technologies as anyone. It would be hard to overstate how immersed, obsessed even, I was in this bright new world of colour and light.

I recently discovered that the television programmes, and more, are freely online in the ‘BBC Computer Literacy Archive’. It has the 1978 documentary which set things off (still informative 45 years later), and Dominic Sandbrook’s wonderfully evocative reflection on the social changes of the nineteen-eighties (not only computers). Incredibly, one programme even shows my own small part in this.  

Watching again now, I am struck by how aware we were of the social questions posed by what was about to come. How would people spend their time in a world with less work? How should wealth be shared across society? It is not turning out as well as it might.

Most fascinating for me is the series ‘The Learning Machine’ (1985), about computers in education, the area in which I worked. Here, once again, are the names and faces I knew and discussed things with at workshops and conferences, such as the main writer and presenter, Tim O’Shea.

He was scathing of the Microelectronics Education Programme, which, he said, had foisted cheap, underpowered computers and poor software upon parents and schools. The attractive message about improving the quality of education, disguised what was really on politicians’ minds: the job market, supporting British industry, and making education cheaper. Eventually, we might even do away with schools and teachers completely.

The then ubiquitous programming language, Basic, comes in for particular criticism. It encouraged tangled, undecipherable code, leading self-taught home and school users to think they knew how to write software, when, really, their knowledge was badly lacking.

I think Tim was broadly correct, but we were all still trying to understand how to use computers in education, and few teachers had the skills to teach programming. I was taught structured methods and had no difficulty creating reliable, intelligible Basic programs several hundred lines long.

It can also be argued that the initiatives did have benefits, but they were two decades in the making. A generation of youngsters became fascinated by computers, seeding Britain’s successful computer games industry. So, perhaps it did work out well in the end. Tim did well too. He became Principal of the University of Edinburgh.

One other series caught my eye: ‘With a Little Help from the Chip’ (1985), about helping those with special needs. I was astonished, in programme 3, to see a one-minute clip of software I designed and coded, being used in a school for deaf children. I have written about the programs before, but never seen the TV programme. It brought back all the satisfactions of going into schools to observe and collect data. 

Do you ever wonder, were it possible, whether you would happily go back to an earlier point in your life? I would, to this time for certain. And I would jump at the chance of another forty years. Most of all, it was an innocent, optimistic time, focused on what we were doing rather than the unrest and disruption taking place. We were trying to make the world a better place. We could do with more of that now. 

* A name used by Margaret Thatcher for Eurosceptic right-wing Conservatives. 

Proof of the Pi

The proof of the pudding, they say, is in the eating, but what about the proof of the pi?

The ancient Egyptians, the Babylonians, Archimedes and blogger Bob Brague will tell you that we need pi (π) for circle geometry, and that it is roughly 3.14159. Blogger Yorkshire Pudding will also tell you that we need pie, lots of it, but he would be referring to the kind he makes from minced meat topped with mashed potato and baked. Yorkshire Pudding is right. There is no need for mathematical constants and strange symbols. We only need to know that the distance around the circle of a shepherds pie, as near as dammit, is three and one-seventh (22/7) times the distance across. You can use this to ensure you are baking enough for everyone. 

I took for granted what they said about pi at school, without any real understanding. If understanding is the ability to think of the same thing in different ways, and to be able to switch between them, this is my attempt to do that. 

So, this is another mathematical post, like the one in January about the Pythagoras theorem. I wondered whether the same technique could be used to illustrate similar concepts; such as pi.  

Here is a circle of 14 units across, zoomed in on the top right-hand quarter to make it easier to see and count. The quarter-circle is 7 units high, and it takes 11 units to go around its edge. So to go all the way round the full circle would take 44 units, which is three and one-seventh times the distance across the whole circle (14 x 22/7 = 44). 

Does it also work for area? Can it show that the area of a circle is three and one seventh times the area of a square fitted from the centre to the edge (American: Area = πr²)? 

Here is the circle again, with a square drawn from the centre to the edge, zoomed in on one quarter. 

If the square is divided into a 7 by 7 grid of 49 smaller squares, then most of the smaller squares are inside the circle, but some are outside. Of those outside, some are complete squares while others are part-squares. Counting them, I reckon that a total equivalent of around 10½ smaller squared are outside the circle, leaving 38½ inside. I have tried to show how I counted 10½ by putting numbers on the quarter-circle. Those with the same numbers make up one square. 

Multiplying this by 4, it would need 154 (38½ x 4) of the smaller squares to completely fill the full circle. This is equal to three and one-seventh times the 49 in the square on the radius (49 x 22/7 = 154). 

To prove this visually, I used three larger squares to cover three-quarters of the circle. Then I moved the parts that were outside the circle (shown in grey) into the fourth quarter. So far, in all, this has used 3 larger squares, a total of 147 smaller squares. 

But it does not quite cover all the fourth quarter of the circle. We need an extra 7 smaller squares (shown in yellow), in other words, one-seventh of a larger square.  

So, the area of a circle is equal to three and one-seventh times that of a square drawn from the centre to the edge. (Area = πr²)

Arithmetically, it takes 38½ smaller squares to fill the fourth quarter, but there are only 3 x 10½, or 31½, available to move. We are 7 short. 

I get it. At least I think I do. 

Pythagoras

It was well-known to the ancient Egyptians, that a triangle with sides of 3, 4 and 5 units makes a right-angle. The Babylonians also knew this four thousand years ago, as they did in India. They used it to measure out precise squares and verticals. I would not be surprised if the ancient Tom Stephenson used it too.

Rotate such a triangle four times by ninety degrees, and you are back to where you began. Put four of them together as shown below on the left and it makes a perfect square. The one on the right is the same with the middle bit filled in.

This works for any right-angled triangle, not just those of size 3-4-5. 

The sides of the square are equal in length to the long sides of the triangles.

I am now going to move the top two triangles, top right to bottom left, and top left to bottom right. Hopefully, the arrows and numbers help make this clear. It results in an L-shape.

The L-shape uses the same pieces as the large square we started with, so the overall area remains exactly the same.

The L-shape can be split into two squares, a large one and a small one, as below. The sides of the smaller square are of the same length as the shortest side of the original triangle (see right-hand side). The sides of the larger square are of the same length as the third side (see left-hand side). 

The two squares still use the same pieces as the large square we started with, so the total area remains exactly the same as it was before we moved things around. 

In other words, the area of the square formed around the longest side of the triangle is the same as the combined areas of the squares formed around the other two sides. 

Or as Pythagoras put it in 550 B.C.: “The square on the hypotenuse is equal to the sum of the squares on the other two sides.” 

Isn’t that just exquisite. They never showed me that at school.

Pythagoras may have discovered this by moving triangles around in the same way, one of the first to express the structure of nature as numbers, and advance understanding from the world of fact into the world of proof. He offered a hundred oxen to the muses in thanks for the inspiration (Jacob Bronowsti: The Ascent of Man).

And once you know this is true for any right-angled triangle, you can work out how much timber and how many tiles you need for your pitched roof, and are on the way to the kind of trigonometry that allows you to manipulate three-dimensional images on your computer screen. 

Wilson, Keppel and Betty

I call them Wilson, Keppel and Betty. They live inside my brain. I think they are three, but there may be more than one Betty. They are not the Wilson, Keppel and Betty some may remember, if anyone does, although, just the same, they sprinkle sand and scrape it around with their feet.

Betty, however many there are, is not too bad. She is not there all the time. She tries to make you forget things. Like when you know the name of the author of ‘Goodbye to Berlin’, but some cocky little sod from Edinburgh or Oxford shouts out Christopher Isherwood on ‘University Challenge’ while you are still thinking W. H. Auden, which you know is near but not quite right.

I can just about cope with Keppel. He makes your mouth slack and flobby, and blurs your words, but only when you are low on blood sugar. Others say they have not noticed, but that is how it feels to me.

No, Wilson is the worst. He used to put swirling patterns in my eyes. Dr. Hatfield tried to zap him away, but he came back. Mr. Thomson said he would cut him out, but he would not be able to cut all of him out, he would have to leave bits behind.

So Wilson is still there. He now blanks out a space just to the right of my point of focus, and if you can’t see the next             along a line of              then you can only read one word at a             rather than fluently. I should learn mirror-reading, right to left. He also moves words along, and up from the line below, and puts them where you are reading now, slows which letters slows things down even more. And, sometimes, he makes you look at letters for ages before you see what they are, and makes you write an M for a B, or a D for a P, or an S for C. He is a                        total                      mactarp. I have to get the computer to read things out, or Mrs. D.

They have stopped their sand dance for now. So long as I keep taking the Tepmetko Tepotinib they will be quiet. They don’t like it. It makes them ill. It makes me ill too, but not as ill as it makes them. Dr. Brown says that one day they will decide they have had enough and do away with me. It might be this year, but we thought that this time last year, so who knows? Perhaps they realise that if they do away with me, they do away with themselves as well. Mactarps!

https://youtu.be/pkhJpr2zR8s

The Mighty Micro

New Month Old Post: first posted 4th January, 2017. 

In 1978, Dr. Christopher Evans, a psychologist, computer scientist and expert on the future of computers, confidently made four predictions for the year 2000: (i) the printed word would become virtually obsolete; (ii) computer-based education would begin to supplant schools and teachers; (iii) money, in terms of physical bits of metal and paper, would almost have vanished; (iv) substantial and dramatic advances would have taken place in the field of artificial intelligence.
 
His only uncertainty was about the pace of change. It might take a decade or so longer, or occur more quickly, but the changes about to take place would be so stupendous as to transform the world beyond recognition. There would be more changes than in the whole of the two previous centuries. We were about to experience rapid, massive, irreversible and remorselessly unstoppable shifts in the way we lived.

Evans expanded his predictions in his book and television series The Mighty Micro. As well as the four main predictions, he thought we would soon see self-driving collision-proof cars, robotic lawn mowers, doors that open only to the voices of their owners, the widespread commercial use of databases and electronic text, a ‘wristwatch’ which monitors your heart and blood pressure, an entire library stored in the space of just one book, a flourishing computer-games industry and eventually ultra-intelligent machines with powers far greater than our own. Every one of these things seemed incredible at the time.

The social and political predictions were even more mind boggling. Evans foresaw a twenty-hour working week for all, retirement at fifty, interactive politics through regular electronic referendums, a decline in the influence of the professions, the emptying of cities and decreased travel as we worked more from home, and the fall of communism as underprivileged societies become astutely aware of their relative deprivation.  

I remember how fantastic and exhilarating this view of the future seemed at the time, but it gave me a serious problem. Having escaped my previous career in accountancy, I was half-way through a psychology degree trying to work out what to do next. If Evans was to be believed, and I believed a lot of it, then most of the then-present ways of earning a living were in jeopardy.

What was I to do? The answer seemed obvious: something that involved computers. So like Evans, I looked for ways to combine psychology with computing, and after gaining further qualifications that is what I did.

Dr. Christopher Evans talks about educational software

It is fascinating to revisit Evans’ predictions. How many were correct, what would have surprised him, and why? Many commentators conclude he got more things wrong than right, but I am not so sure. The printed word no longer predominates; computers now pervade education, albeit with teachers in schools as guides rather than in the didactic and solitary way Evans imagined; and nearly all significant financial transactions are carried out electronically. And the less-bizarre predictions are already here.

Undoubtedly, he over-estimated the pace of change, especially the emergence of advanced artificial intelligence. Futurologists are still predicting it. Stephen Hawking warned of the terrifying possibilities of machines whose intelligence exceeds ours by more than ours exceeds that of snails. On the other hand, it may still be as far away as ever. It remains unclear what qualities such super-intelligence might have, or whether intelligence might have an upper limit. Perhaps our inability to imagine these things defines our stupidity. Where Evans was wrong, if it can be regarded as wrong, is that he was no seer. He could not escape the prevailing mindset of the nineteen-seventies, and foresee the innovative new uses of computers.

He did not foresee the internet. Multimedia crops up only in the form of a brief mention of “colour graphics”. Graphical user interfaces were still little more than a research project. He thought that electronic communications would take place through “the family television set” rather than personal hand-held devices.

And if you could not foresee these things, there is no way you could imagine how they would be used. Evans, with a seemingly naive view of human nature, imagined we would all be using computers to improve ourselves and make our lives easier; that our leisure time would be devoted to cultural, artistic, philosophical, scientific and creative endeavour of various kinds. I wonder what he would have made of internet pornography, fake news, selfies and cat videos.

Evans’ over-beneficent view of human nature coloured his vision of the social and political changes he thought would take place. Take the twenty-hour working week and retirement at fifty. The efficiencies brought about by computers could already have reduced our work significantly, but this has never been offered. It would upset too many powerful interests. Governments answer to the establishment more than the ‘man in the street’. As a result, for those who have jobs, the trend today is the opposite. And for those who don’t, wouldn’t it be fairer to share the jobs out?

Imagine if twenty hours per week up to the age of fifty was all we had to do. What would happen? For a start there would be those who decided to take on additional work in order to fund superior accommodation, private education, health care, better holidays, a more luxurious lifestyle and a more comfortable old age. Anyone content with just one job would begin to lose out. To keep up, we would all continue to work more than necessary, and the extra wealth would evaporate through increased spending, inflation and rising house prices, and disappear into the pockets of the elite minority, much of it overseas. Does that sound familiar? The only way to avoid the inevitable self-satisfied winners and miserable losers would be to ration the amount of work one could undertake, or the amount of wealth one was allowed to have. The necessary laws and financial penalties would be unpopular and difficult.

And how would we use our over-abundant spare time? One could easily imagine an intensification of social ills: epidemics of obesity, alcoholism, drug dependence, mental health issues and the breakdown of law and order. 

‘Parkinson’s law’ prevails: work expands to fill the time available. Anyone with experience of large organisations will know how work once considered inessential or unaffordable, now occupies an entire additional workforce who administer quality, accountability and ‘political correctness’. Rather than reducing the overall workload, computers have increased it by making possible what was once impossible.

Stephen Hawking concluded his forewarnings about super-intelligent computers as follows:

“Everyone can enjoy a life of luxurious leisure if the machine-produced wealth is shared, or most people can end up miserably poor if the machine owners successfully lobby against wealth redistribution. So far the trend seems to be towards the second option, with technology driving ever-increasing inequality.”

Sadly, Christopher Evans died shortly after his book’s publication, three weeks before his television series was broadcast. It is often said that if you make predictions about the future the only certainty is that you will be wrong. Evans would have known this, but I suspect he would have been fairly satisfied by the extent to which he got it right. 

My original post in 2017 was quite a lot longer and included links to the archived television programmes, so I have left it here. The programmes are fascinating to watch if this kind of thing interests you - the future as seen in 1978.

Exon 14

To paraphrase "GPs Behind Closed Doors", this post contains challenging medical issues.

Exon 14 sounds like a science fiction film. As little as ten years ago, it could well have been, but actually it is real.

I have something called the MET Exon 14 skipping mutation. It alters a specific gene, the MET gene (mesenchymal-epithelial transition) so that affected cells produce an abnormal protein which makes them grow uncontrollably.

The mutation causes lung tumours. It affects mainly smokers, but I put mine down to dirty Leeds in the nineteen-seventies when large numbers smoked, and offices, buses, cinemas, pubs and the shared houses I lived in reeked of a blue haze that stuck to your hair and clothes so much that you failed to notice. Leeds was also full of traffic fumes and pollution from coal fires and industries, and my accountancy job involved hours walking round warehouses, mills and factories where there were all kinds of dust and chemical vapours. The cause on my health record is "significant passive smoking". 

I was entirely symptomless until I had a seizure. Perhaps a routine chest X-ray might have detected it sooner and saved me a lot of trouble, but it was as good as impossible to get one during the covid lockdown, even if I had thought to request one.

Diagnosis begins with a CT-directed lung biopsy. You lie face-down in a CT scanner while a surgeon positions a thing metal tube into your back, through which they can then cut out and remove a small piece of tumour tissue for analysis and gene-sequencing. It is not a comfortable procedure. I wondered what was the cold liquid running into the back of my throat, which I had to spit out on to the scanner table. It was blood. We don't normally realise how cold the insides of our lungs get.

Gene sequencing is only the first part of the science fiction. There is a targeted therapy. The Merck drug company have licenced a chemical called Tepotinib (trade mane Tepmetko) in the form of a daily pill that blocks the abnormal protein, and slows down or stops the tumours from growing. It is a high cost treatment; I have heard a figure of £7,000 per month mentioned, but thanks to the NHS I do not have to pay.

Surprisingly, it is a relatively simple chemical - a hydrochloride hydrate of C₂₉H₂₈N₆O₂. I imagine that in some parts of the world they ignore the patent and make it themselves for a few pence per pill.

I have had other treatments too: chemotherapy which was awful, lung radiotherapy which was little trouble in my case, gamma knife radiotherapy which pinpoints and zaps small brain metastases, a brain op to drain the cyst that gamma knife left behind, which was scary. All over a year ago.

The side effects of Tepotinib are difficult, especially oedema (fluid retention). If you get cold it takes ages to get warm again because it is the equivalent of having 20 pounds (9 kg) of cold water bags strapped around your limbs and body, and, believe me, you would not want to have scrotal oedema (or vulval oedema I imagine, but don't know because I don't have that).

I am OK. It is but a scratch. I've had worse. None shall pass. I am still here.  

So, not only have we mapped the human genome to identify the 25,000 or so genes of our 23 chromosomes, we can gene-sequence malfunctioning cells to pick out a defective gene, understand its mechanisms, and construct a chemical to block its actions. To those of my generation, even the technologically literate, that really does sound like science fiction.

New things like this are coming along all the time. It should give hope to those who might become ill in the future.

Molly’s Family

One of the perks of working in a university is that you get to play with the latest bits of kit.

I was asked to get involved in one of the new multimedia courses springing up around the U.K. in the mid nineteen-nineties. Surprisingly, many were in engineering departments. I believe the first was started by engineers at Bradford University around 1993.

One element of our new course was digital video. We were all encouraged to understand how it worked. As a result I was allowed to borrow one of our new hand-held video cameras and take it home. It was great fun filming our children when little, playing in an inflatable dinghy in the natural pool on the beach at Sandsend.

I know that sounds like a frivolous waste of taxpayers’ money, but we needed to know how to use these new technologies ourselves, and understand how they might relate to other parts of the course and what their possibilities might be. Silicon Valley technology companies often allow staff time to ‘play’ with new software and equipment because it generates innovative ideas. In our case, it led to course developments and research funding. 

Handling a video on a computer was not straightforward then. You had to run it through programs to digitise and ‘render’ it into a viewable form. You needed to be aware of the type of video coding (‘codec’) you were using. Only then could you begin to edit it or write programs to do state-of-the-art clever things such as spotting objects and faces. There would be a lot of ‘re-rendering’. Computers were so slow that every stage took ages. Nothing was automatic and effortless like now.

Back home, I realised that the camera made it easy to create stop-motion animation. With my then eight year-old daughter’s lovely wooden dolls’ house, the figures that went with it, and her enthusiasm and child’s take on family life around her, this, below, was one of our first attempts. Yet another example of something that would be much easier with today’s software. You wouldn’t even need a real dolls house. I know which I think the most fun.

She made up most of the story and moved the figures, while I mainly operated the camera. Surely, the story is not based on her own family, is it?

Weekend in College

(New month old post: first posted 23rd September, 2015)

You been tellin’ me you're a genius since you were seventeen,
In all the time I've known you, I still don't know what you mean,
The weekend in the college didn't turn out like you planned,
The things that pass for knowledge, I can't understand.

It was as if Steely Dan’s phenomenal ‘Reelin’ in the Years’ was aimed directly at me, cutting through the pretentiousness to the stupidity beneath. It was actually four months but might just as well have been a weekend for all the good it seemed to do. With the anticipation of arrival smothered in a blanket of disillusion, I detested myself as much as the subject of Becker and Fagen’s song.

City of Leeds and Carnegie College

It was the first of two attempts to escape accountancy. After four mind-numbing years, I decided it was not the career for me, and applied to train as a science teacher. You needed five G.C.E. Ordinary level passes, and to have studied your specialist subjects to Advanced level. In other words, you did not actually need to have passed the Advanced level. That was me exactly. I didn’t tell them about the failed accountancy exams.

It beggars belief that you could become a Secondary years science teacher with nothing better than weak Ordinary level passes in your specialist subjects. They should have told me to go away and re-sit Advanced Levels and reapply, assuming I still wanted to. Anything less would be to inflict my limited knowledge and ineffectual learning techniques upon other poor innocents. But you can talk yourself into anything if it’s on offer.  

Around 1960

The City of Leeds and Carnegie College, now part of Leeds Beckett University, was one of the loveliest campuses in Britain. It was built in 1911 in a hundred acres of parkland that once belonged to Kirkstall Abbey. Hares ran free in the woods and each spring brought an inspiring succession of leaf and flower. The magnificent main building dominated a sweeping rectangular lawn called The Acre, lined by solid halls of residence named after ancient Yorkshire worthies: Fairfax, Cavendish, Caedmon, Leighton, Priestley, Macauley and Bronte.

But instead of moving into halls, I remained off-campus in my seedy shared house. It meant not taking full part in the friendly community of cosy study bedrooms around the grassy Acre, and the activities I might have enjoyed. I felt old and awkward. The music drifting from open doorways flaunted the easy friendships within. While the Carpenters sang that they were on top of the world, Steely Dan mocked that “college didn't turn out like you planned”.

The course quickly became tedious. Chemistry classes were interminable, like being back at school. I began to sink into the old malaise and find fault in everything. A biology technician “humanely” despatched rats for dissection by cracking their necks on the edge of a bench. We sampled the vegetation growing on The Acre lawn, my accountant’s brain adding up the data almost before the other students had got out their calculators. In English classes, reading through a play, I realised that some of the others were not fluent readers. It was astonishing. They were training to be teachers for goodness’ sake.

We were sent out on teaching practice. I found myself in a Comprehensive School on a council estate. After two weeks, we were asked to plan and teach a small number of lessons ourselves. I had good ones and bad ones. In the best, observed by the teaching practice tutor, the children used Bunson burners, all happy and engaged in what they were doing. Do they still let them do such dangerous things? Fortunately, no one saw the worst from which I was saved only by the school bell.

The school had none of the liveliness of the grammar school I had attended myself, and staff made no secret of their dissatisfaction. “Here I am with a First in English,” said one, “and I’m supposed to teach kids who have no interest in reading anything at all.” And one of the most inspiring teachers left to open a pottery.

Despite good marks, the doubts grew as I returned to my old employer to earn money over Christmas. The uninspiring course, the mediocrity, the dismal school I’d seen, it was not what I wanted. It was not a substitute for university. More hopes and dreams dashed by another abandoned course. What now?

I was by no means the last to leave. A few went on to successful teaching careers, but many never taught at all. During the year that my course would have finished, the press was rife with accounts of unemployment among new teachers. Despite a chronic shortage just two years earlier, Governments had not planned for the falling birth rate. Around two thirds of newly qualified teachers were unable to find jobs.

One poor girl in London had previously been guaranteed a post, but after staying on at college an extra year to improve her qualifications with a Bachelor of Education degree, she now had to find work outside teaching. Perhaps it was fortunate I did leave.

It was thirty years before I visited Beckett Park again. The passage of time gave rise to quite an unsettling experience. I was haunted by half-remembered faces and snatches of conversation from a particularly intense episode in the past: here is where I usually managed to find a parking space for my Mini; across there is where I resented a tutor telling me I would have greater authority if I stood straighter and walked with shorter steps; that window, in Leighton Hall, is the study bedroom where a girl I seriously fancied took me one afternoon for nothing more than a cup of coffee and a long talk.

Ghosts aside, the place looked much the same. Most of the original Edwardian campus survives, although the internal use has changed, such as residences replaced by staff offices and teaching rooms, with students bused-in from off-campus and financed very differently.

Smoke gets in your eyes. You can convince yourself anything is right when you’re desperate enough.

[The original post was even longer and more over-written than this, but if you are interested, it is still here]

School Chemistry

New month old post. First posted 14th November 2014

There was once a time when things at school looked promising. I was doing well in most subjects, especially science. My diary remembers I was top in biology, had got 20/20 in a chemistry test, and had enjoyed a ‘fab’ physics experiment: the water equivalent of a copper calorimeter. Yet I only scraped through ‘O’ levels and messed up ‘A’ levels completely. What went wrong? 

I was spellbound by the science labs the moment I went to grammar school. They had a permanent smell of pungent chemicals, coal gas, rubber tubing and wood polish that hinted at mysterious secret knowledge. What went on at those dark ancient benches with sinks, gas taps and glass-stoppered bottles etched with intriguing names: tincture of iodine, nitric acid, sodium hydroxide, lime water? Could they make explosives and powerful poisons? Could they turn base metals into gold? Did they have the philosopher’s stone with the secret of eternal life? Perhaps if you paid attention, you might have these things too.

In a room tiered like the Royal Institution, you looked down from beautiful oak benches upon Dr. Page as he heated potassium chlorate and manganese dioxide to make oxygen. It bubbled up through water into an upturned jar. He became a wizard, an alchemist, showing how it reacts with other substances. “Magnesium burns with a bright white light” he said, conjuring a dazzling ball of light too bright and too white to look at.

In biology, my dysfunctional memory absorbed the names of anatomical structures and physiological processes: xylem, islets of Langerhans, osmosis, mitochondria, mitosis. In physics, I was captivated by the sheer ingenuity of the procedures. In mathematics, the interactions of shapes and numbers seemed as exquisite as any art form.

And what a cheat! We listened to a weekly series of science programmes on the wireless. I might have been the only person in the class with a tape recorder. I showed my mother how to record the programmes at home and, after listening a second time, handed in outstanding essays.

But things began to go downhill. I have excuses, such as forgetting to revise for the summer science exam. “Position in class 2nd, position in exam 25th, a disappointing exam result” said my report. It put me in the second stream for science, where people messed about and I made the mistake of wanting to be liked. Things got harder too. Chemistry progressed from observation to experiments, quantitative measurement and atomic models. And we moved to new labs with benches in rows rather than islands, where teachers couldn’t see what was going on at the back.

The once admired Dr. Page, little and thin with an odd toothy mouth, small bony face and permanent worried frown, was not well equipped to deal with continuous low level disruption. An orchestra of clicks and pings from cupboard door catches and drawer label holders would start up every time he turned to write on the blackboard, only to be met by silent, innocent faces when he angrily spun back.

Occasionally he would catch someone still smirking, attributing blame by shouting their name: “Bullard!”, “Gelder!”, “Dunham!”. Geoffrey Bullard perfected the ability to click a cupboard door with his foot while the rest of him remained motionless, his face expressionless. He could continue this covert clicking after Dr. Page had spun, causing someone else to laugh and get the blame.  

Harvey Gelder started a league table of called out names. Geoffrey Bullard went straight to the top when he caused uproar by catching a wasp and dropping it into a bottle of sodium hydroxide. It didn’t half fly around fast inside the bottle.

It wasn’t long before everyone at the back had points except for Maurice Jupp. He remained bottom of the league until almost the end of term. The day arrived when, under conditions of intolerable harassment, Jupp was spotted not sitting quietly and had his name called out. We all stood up cheering and applauding. We had to stay late that day.

Jupp’s downfall was brought about by water. The bench water taps could not have been better designed for mischief. They were of the typical laboratory downspout design, and could be turned on just enough to drip so that a well-timed finger could flick drops of water at the head of the person sitting in front. Or, the top of a fountain pen, the kind with a small hole in the side for equalising air pressure, could be pushed on to a tap to squirt a powerful jet of water at someone sitting yards away. The rubber teat from a teat-pipette could do the same job if you made a tiny hole in it, except the spray was so fine that the recipient might not notice until the back of his jacket was soaked through. And a teat without a pin hole pushed on to a dripping tap would slowly expand like a balloon until it became a water bomb primed to explode. There was not a lot you could do about it. Pulling off the teat was suicidal. The best thing was simply to turn off the tap, hoping you had correctly remembered which way was off, and trust that the thing remained stable.

Hardly anyone from the back of that class passed their ‘O’ level chemistry.

Dad’s Thursday Helper

New month old post (first posted 18th August 2014)

Thursday afternoon was half-day closing. The whole town seemed to shut down. Retail businesses got the afternoon off in part-compensation for being open on Saturdays. So, Dad came home and Mum went off to Grandma’s leaving him to get on with his Thursday afternoon jobs. I ‘helped’.

 

We cleaned and brushed his boots and shoes, black and brown, with Cherry Blossom polish from a round tin with cherries on the lid, and Wren’s waterproof dubbin with a little bird. 

We replaced brake blocks and pumped tyres, and mended punctures by immersing the inner tubes in bowls of water to see the bubbles, marking with chalk, and sticking on puncture patches with stringy rubber solution. I learnt about tyre levers and tubular (box) spanners. We polished the wheels and handlebars with rags (old underpants were good) and mustard coloured chrome cleaner, transforming dirty grey to silver shine. We smeared on vaseline for protection from the weather – a magnet for yet more grime. 

We soaked the chains in trays of petrol to remove the oily grit, and then disposed of the petrol by setting it alight. Dad once just tipped it on the garden but had to stop after Grandpa came for tea one day and complained: “This lettuce tastes of petrol.” 

We cleaned Dad’s pipes, scraping out the burnt black ash with a gadget barbed like a miniature medieval mace, and soaking up the evil-smelling gunge with fluffy pipe-cleaners.

Then it was time for nicer smells and sounds: the matchsticks that rattled in their flat green and red box with a picture of a swan on the top, the firework hiss and smell of sulphur when he struck one, and the clouds of sweet St. Bruno smoke. He would pack the pipe bowl with tobacco from a black and white metal tin (with new tins, you had to pull a rubber vacuum seal from the bottom before you could open the lid), put the stem between his teeth, suck a flame down into the bowl, and blow smoke from the side of his mouth with a satisfied expression and popping ‘p’ sound.

“Can I have a puff?” I begged. “Let me have a puff”. I was only four.

“Oh all right,” said Dad reluctantly. He held the stem of the pipe near my mouth. I was instantly sick. 

And then there were the fun jobs – playtime. We had a model steam engine, the “steam boiler”, which drove a flywheel through dual pistons, exactly like the one pictured. It had a brass water tank heated by a methylated spirit burner that slid underneath. Dad loved to take it out of its oily cardboard box and fire it up on the back room table. Once steam was up, it could be set in motion. The flywheel revolved at a fair old pace, puffing and rattling, spitting out a lethal mixture of hot oil and boiling water. It had a screeching whistle and a safety valve that blew like a railway engine when the pressure got high.

It was important the pistons were always oiled and that the water tank did not run dry. The spirit burner needed topping up frequently. The smell of methylated spirit mixed with hot emulsified oil is unforgettable. Once, we spilled methylated spirit on the table and it caught light. I watched fascinated as a lucent blue pool of flame spread slowly across the surface, Dad flapping it frantically with his hands, looking panicky.

A move to another house brought a whole new set of Thursday afternoon jobs, sanding and painting skirting-boards and staining wooden floors around the edges of carpet squares before fitted carpets became the norm. 

We painted the garden shed banana yellow. It leaked, so we mended the roof. I sat up there with Dad, ‘helping’ him tack down new sheets of roofing felt and painting it with hot black tar. Dad heated the tar to boiling point in an old paint pot on the kitchen gas cooker. Then, holding it with just a wooden cane through the handle, carried it bubbling and the smouldering tar acoss the kitchen floor, across the garden, and up on a rickety stepladder and on to the shed roof. It must have been a thoroughly hazardous operation. There were splashes of black tar on the yellow paint for years.

But there was still room for play-jobs. 

We found some old lead piping in the shed. Dad melted it on the kitchen cooker in an empty tin can, and then, holding it with pliers, poured the molten metal into toothpaste tins which had originally contained hard, flat, tablets of ‘dentifrice’ wrapped in red cellophane. You rubbed it with a wet toothbrush to form a lather. The empty tins were just right for moulding make-believe medals – possibly something Dad had himself made in this own childhood. After pouring the lead, the medals were dropped into a bowl of water and sizzled as they cooled. The embossed ‘Gibbs’ lettering transferred perfectly to the moulded medals. No one knew about lead poisoning then.

Perhaps it was just as well Mum went to Grandma’s on Thursdays. 

‘Dad’s Thursday Helper’ would have continued for me until I started school, but Dad was then able to do it all over again with my brother.

Contrails

A few days ago, Tom Stephenson posted an early morning view from his window. Here is ours.

We are close to the border between West and South Yorkshire, beneath transatlantic flights to and from Europe and further afield. For many months our skies have been reasonably clear but this week the U.S.A. removed covid travel restrictions.

Here is our view this morning. Each flight emits several hundred tonnes of carbon dioxide into the atmosphere. 

The Day We Saw The Queen Mary Sail

and C. P. Snow’s surprising digital footprint

(first posted 11th November, 2017) 

My dad was captivated by ships from childhood, when ocean-going liners were the most exhilarating machines ever built. He knew the names and colours of the British shipping lines and some of the foreign ones too: Cunard: red and black funnel, yellow lion on a red flag; Union Castle: also red and black funnel, red cross on a white and blue flag; Peninsula and Oriental: buff yellow funnel, blue, white, red and yellow flag. It was partly why we found ourselves on holiday near Southampton, the first time we had ever been so far from Yorkshire. Once there, it was inevitable we would visit the docks.

As we approached Ocean Terminal, three towering Cunard funnels told us the Queen Mary was in port. Small boat owners vied for passengers to take to see her sail: an opportunity not to be missed.

RMS Queen Mary arriving at and departing from Southampton for the last time in 1967
(two videos, approximately two minutes each - click to play)

We boarded a launch and sped off down Southampton Water leaving the Queen Mary at the quayside. Any doubts as to why we had sailed so far ahead were soon answered. “The Mary’s moving,” our own captain announced, and within a short time she had overtaken us as smoothly and effortlessly as a huge white cloud in a strong breeze, a vast floating palace towering above. Her powerful engines were easily capable of 28 knots (about 30 miles or 50 kilometres per hour) compared to our 6 or 7. We were left bobbing like corks in her wake as she turned into the Solent. Dad remembered the day for the rest of his life.

From photographs and postcards I can work out it was towards the end of August, 1960, during the last dying years of the transatlantic passenger trade. From genealogical web sites, I can pinpoint the precise date as Thursday 25th. The Queen Mary called briefly at Cherbourg before crossing the Atlantic to arrive in New York on Tuesday 30th, a five-day voyage. Not only that, but, incredibly, you can see the ship’s manifest listing the individual names and details of every one of the 1,024 passengers and 1,203 crew under the command of Commodore John W. Caunce. It is an incredible digital footprint.

Many of the first class passengers are googleable, among them two writers, Charles and Pamela Snow. They were the distinguished novelist and scientist C. P. Snow and his equally-accomplished wife, the novelist and playwright Pamela Hansford Johnson, travelling with their son Philip and her teenage daughter Lindsay Stewart. Philip was just one of eighty children on board. Some of them stood on deck and followed that incomprehensible human instinct to wave to strangers in the accompanying flotilla of pleasure boats. I wonder if any of them noticed a ten-year old boy waving back.

At the time, C. P. Snow was enjoying the controversy caused by his Two Cultures lecture the previous year, in which he had lamented the gulf between science and the Arts which he, justifiably, believed he bridged. He had implied that many scientists would struggle to read a classic novel, and that many humanities professors would be unable to explain simple scientific concepts such as mass and acceleration, making them the scientific equivalent of illiterate. Most resented the insinuation that a poor knowledge of science rendered them uneducated and ignorant, including the acclaimed literary critic F. R. Leavis who let loose an astonishingly abusive and vitriolic response. Part of it went:

Snow is, of course, a – no, I can't say that; he isn't. Snow thinks of himself as a novelist [but] his incapacity as a novelist is … total: ... as a novelist he doesn't exist; he doesn't begin to exist. He can't be said to know what a novel is. The nonentity is apparent on every page of his fictions … Snow is utterly without a glimmer of what creative literature is … he is intellectually as undistinguished as it is possible to be.

Leavis continued the attack at length, giving examples of what he said was Snow’s characterless, unspeakable dialogue, his limited imaginative range, and his tendency to tell rather than show. Others jumped to Snow’s defence, suggesting it was in fact Leavis who could not write. It was brilliant, sensational stuff, still talked about decades later. Both academia and the general public, including my dad, soaked up the spectacle in pitiless delight, entertained by intellectual heavyweights slugging it out with metaphorical bare knuckles.

None of this meant anything to me at the time, of course. It would be another twenty years before I discovered and found it greatly entertaining, but my dad would have been fascinated to learn that Snow and his wife were on board. A little more googling reveals they were on their way to spend the autumn at the University of California at Berkeley. Before their return, both, along with the prominent English writer Aldous Huxley and the American Nobel chemist Harold C. Urey, took part in seminars on Human Values and the Scientific Revolution at the University of California Los Angeles on the 18th and 19th of December. The Staff Bulletin described it as “one of the most distinguished intellectual occasions in the history of the University of California”.

If it is possible discover this much about the activities of (albeit well-known) individuals in 1960, one fears to imagine what digital footprints we might leave behind ourselves. Much of what we buy, our social interactions, our medical and educational records, our motoring activities, and so much more, are now all stored on a computer somewhere, possibly in perpetuity. I wonder who is going to be looking at mine in sixty years time.

Siemens A55

(Updated from original post of 22nd June 2016)

There were gasps of astonishment as billionaire Sir Philip Green, answering MPs’ questions about the BHS department store scandal, checked his texts on a cheap, twelve-year-old Nokia 6310. Surely, you would expect him to be able to afford the latest Diamond Rose iPhone.

All kinds of reasons why he might be using such an obsolete device were suggested: the Nokia was made to last; battery life is outstanding; he does not want constant email interruptions; pre-GPS phones are not easy to track; he is penny-pinchingly mean; he likes playing Snake 2. 

Who knows? Maybe all of these. That was in 2016. But I’m still with Sir Philip, especially the penny-pinchingly mean. Here’s mine – even older – a Siemens A55 bought October 2003. It’s a phone. It does texts. It works. And no, I do not play Stack Attack, Balloon Shooter, Move the Box and Wacko.

With O2 Pay As You Go, you have to top up at least once every 999 days so as not to lose your account and credit balance. My diary (paper of course) noted I next needed to top up before 13th July, 2016. £10 would see to it. There is also a usage requirement but a weekly text from the bank meets that. Some weeks I forget to switch it on.

NOVEMBER 2018 

Sir Philip was in the news again with unflattering revelations about his other behaviours and attitudes. I added a note emphasising I did not share them. For example, I do not iron creases in my jeans (for comic effect I wanted to add that my wife does it for me, but actually I iron my own jeans). I still had my ancient phone, though. 

AUGUST 2021

I still have it. I still use it. Will it make twenty years? Or will I have to get a smartphone to go places, buy things and prove my vaccination status? Even King Canute was forced to get one in the end.

I know it’s eccentric and appreciate that smartphones can be useful, but I’d hardly use one. I also fear what I’d be like. It’s something to do with having worked with computers. I like the idea of not being instantly contactable. I’d be constantly fiddling with it while eating, or fact checking during conversations. I like to let thoughts take their course rather than being hijacked first thing in a morning. That’s why I try not to switch on the computer until I’ve done at least a couple of jobs, like ironing jeans. The daft thing is, I could probably program them (phones not jeans, although maybe when we get smartjeans...).

Brugada Syndrome

Some fifteen years ago, my youngest cousin had a cardiac arrest. His heart simply stopped. He got up during the night and was found downstairs on the floor in the morning. He had been absolutely fine the previous evening. He was thirty-one. The funeral was a wretched affair in pouring rain. 

His father, my uncle, died in a similar way aged thirty-nine. He was eleven years my elder, fourteen years younger than my mother. It was one of the few times I saw my mother cry.

Going back even further, my grandfather also died suddenly of heart failure at the age of fifty-six. None had any obvious warnings, although my uncle and cousin both experienced dizzy spells. Concerns that it might be some kind of inherited condition were not taken seriously until more recently.

In part, this was because of the very public incident involving the Bolton Wanderers footballer, Fabrice Muamba, who collapsed during a televised match in 2012. He could not have been in a better place. He received immediate attention, and, in another stroke of good luck, a consultant cardiologist attending the match as a fan ensured he was taken to a specialist coronary unit where he recovered. His heart stopped for 78 minutes and he received fifteen debrillator shocks.

This led to greater awareness of Sudden Arrhythmic Death Syndrome (SADS, not to be confused with Seasonal Affective Disorder, or SAD). There are several kinds – Muamba has hypertrophic cardiomyopathy – but taken together, SADS kills at least 500 people a year in the U.K. at the average age of 32. It is under-diagnosed, with some deaths probably put down to drowning, falling or road accidents. 

Two further cousins, half-sisters of the one who died, insisted on investigations. They were referred to the Inherited Cardiovascular Conditions Service at Leeds General Infirmary where they were diagnosed with Brugada Syndrome, an inherited condition which disrupts the flow of sodium ions into the heart muscle, causing abnormal heart rhythms. These rhythms are so infrequent as to be difficult to spot. Often, there are no symptoms at all. In other cases there may be dizziness or fainting. Sometimes, the first time it shows itself is through fatal cardiac arrest, often during sleep.

Because Brugada is an inherited condition, and there being no surviving intervening relatives, it was recommended that all the cousins be tested.

Now, having reached such an age that I would probably have dropped dead decades ago if I had Brugada, I am not particularly concerned for myself. However, I am occasionally aware of brief palpitations. Weeks can pass without anything and then I’ll get three or four the same day. It seemed sensible to be tested for the sake of my children.

Last June, nearly two years after seeing my G.P., a letter came from Leeds asking me to attend on two successive days – surprising as it was during the pandemic.

The first appointment was to get a Holter monitor: a phone-sized device to record heart activity over time. For the next 24 hours I carried it around and went to bed with its electrodes stuck to my chest. It had a button to press if I experienced any symptoms, which I did twice on feeling a few ‘flutters’. 

The second appointment was for further tests: most significantly a 12-lead electrocardiogram (ECG) and a transthoracic echocardiogram which uses ultrasound to look at the structure of the heart in motion. It was a relief to be told everything was fine (well, the blood pressure wasn’t on that particular day, but I wrote about that last year). Although these tests rule out a number of SADS conditions, they do not rule out Brugada. This requires a further diagnostic test: the Ajmaline provocation test.

The Ajmaline test aims deliberately to trigger the specific ECG pattern that occurs in Brugada. It does not produce the pattern in those who do not have Brugada. My cousins’ abnormal rhythms were observed only during the the Ajmaline test. After another ten-month wait, my name reached the top of the Ajmaline list in March. Again, it surprised me they were still testing during Covid, but as with any potentially fatal condition, it seems right to be doing so.

I thought it would be carried out in a clinic like the first set of tests. I didn’t expect to be in a hospital ward, in a cardiac bed, surrounded by seriously ill patients. The man beside me was just coming round after an angioplasty and stent operation. An older man opposite had been in since a heart attack some weeks earlier, and was waiting for the same operation the next day. A younger chap had a congenital hole in the heart, which had been causing his oxygenated and de-oxygenated blood to mix, not detected until his thirties when he had suffered a stroke. And there was I, apparently nothing wrong, occupying a bed for three hours, most of which was waiting for the effects of the test to wear off. It felt tactless afterwards wishing them good luck and walking out.

Basically, what they do is connect you up to an ECG machine and gradually inject you with Ajmaline to see whether it causes the abnormal Brugada rhythm. I had to sign a consent form. The specialist nurse practitioners who carried it out described the odd sensations you might experience, none of which I had, and the terrifying things that can go wrong, none of which they had never known despite carrying out the procedure up to a dozen times a week.

You get the result straight away. I do not have Brugada. They sent me a letter listing some of my ECG readings: the PR interval, the QRS interval, the QTc, the J point elevation, the V1 and V2 rSR patterns in the second and third intercostal spaces…   

Me neither! But it does mean that my kids should be all right and do not need to be tested. They also picked up my occasional brief tachycardia on the Holter monitor but said it was absolutely no cause for concern unless it becomes frequent or sustained.

None of my diagnosed cousins’ children have Brugada either. Apparently there is no gene mutation in the family, so where it came from, and where it has gone, remains a mystery. Some of my other cousins, even my late cousin’s brother and son, head-in-sand, have decided not to have the tests: “I’ve got too many genes already,” one said.

I’m glad I did get tested. In effect, I’ve had a thorough heart checkup and passed, all free on the wonderful NHS. Privately, it would have been done sooner, but the costs (three appointments, various tests, half a day in hospital, a follow up phone call) could have been prohibitive , leaving us worrying and wondering.